Scavenger Receptor Class B type I (SR-BI）
Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1 (CLA-1); CD36 antigen-like 1
Scavenger receptor class B type I (SR-BI) is a physiologically relevant HDL receptor that mediates the selective uptake of HDL-derived cholesteryl esters (CEs) in vitro and in vivo. SR-BI is a member of the class B scavenger receptor family, which in mammals includes the cluster determinant 36 (CD36) family, lysosomal integral membrane protein II (LIMPII, a lysosomal protein), and SR-BII, an SR-BI isoform with an alternative C-terminal cytoplasmic tail. SR-BI is primarily located on the cell surface, where its expression is regulated by trophic hormones (adrenocorticotropic hormone [ACTH] or the gonadotropins luteinizing hormone [LH] or follicle-stimulating hormone [FSH]), as well as regulating steroid hormone production. SR-BI affects the function of multiple vascular cells associated with atherosclerosis. SR-BI is also involved in regulating platelet function and mediating platelet-HDL interactions[1].
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Scavenger Receptor Class B type I (SR-BI） Produits associés (12)
Produits associés (12)
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ITX5061
0 ImagesITX5061 is an orally active type II non-competitive p38 MAPK inhibitor. ITX5061 increases HDL-C levels by inhibiting SR-BI activity. ITX5061 also moderately elevates ApoA-I levels. ITX5061 reduces early atherosclerotic lesions in the aortic arch of mice fed an atherogenic diet. ITX5061 can be used in the research of atherosclerosis.
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Anti-CD36 Antibody
0 ImagesCat. No.: HY-P990352Pureté: 99.43%Synonyms: Ona36Anti-CD36 Antibody is a humanized antibody expressed in CHO that targets CD36. The Anti-CD36 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD36 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
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Zovostotug
0 ImagesSynonyms: OR-2805
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ML278
0 ImagesCat. No.: HY-19616CAS No.: 1604821-43-3ML278 is a scavenger receptor-BI (SR-BI) inhibitor with an IC50 of 0.93 nM in mice. ML278 inhibits SR-BI-mediated lipid uptake, enhances the binding of high-density lipoprotein (HDL) to SR-BI, blocks the uptake of oleoylcholesteryl ester from HDL, and reversibly inhibits the efflux of free cholesterol to HDL particles. ML278 can be used in studies related to atherosclerotic coronary artery disease.
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ITX5061 free base
0 ImagesCat. No.: HY-122068CAS No.: 848144-15-0ITX5061 free base is an orally active type II non-competitive p38 MAPK inhibitor. ITX5061 free base increases HDL-C levels by inhibiting SR-BI activity. ITX5061 free base also moderately elevates ApoA-I levels. ITX5061 free base reduces early atherosclerotic lesions in the aortic arch of mice fed an atherogenic diet. ITX5061 free base can be used in the research of atherosclerosis.
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BLT-3
0 ImagesCat. No.: HY-120433CAS No.: 109940-24-1BLT-3 is an inhibitor of scavenger receptor class B type I (SR-BI) that exerts reversible, non-cell-type-specific inhibitory effects on SR-BI-mediated lipid transport. BLT-3 inhibits SR-BI-mediated selective lipid uptake from HDL as well as cholesterol efflux from cells to HDL. BLT-3 enhances the binding of HDL to SR-BI. BLT-3 is applicable to research related to atherosclerosis and coronary heart disease.
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PLT012
0 ImagesCat. No.: HY-P991911Pureté: 98.90%PLT012 is a humanized IgG4 antibody targeting CD36. PLT012 inhibits the lipid-binding domain of CD36. PLT012 blocks CD36-mediated metabolic adaptation in regulatory T cells (Tregs) and CD8+ tumor-infiltrating lymphocytes (TILs), thereby inhibiting tumor growth and shifting the tumor microenvironment from immunosuppressive to immunosupportive. PLT012 reduces intratumoral Tregs, enhances CD8+ T cell infiltration and cytotoxic function, and increases the abundance of progenitor-exhausted T cells. PLT012 exerts robust antitumor activity and synergizes with anti-PD-L1 or standard-of-care regimens (anti-VEGF + anti-PD-L1). PLT012 can be used for hepatocellular carcinoma, colorectal cancer and solid tumor research.
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HDL376
0 ImagesSynonyms: SDZ-HDL 376HDL376 is a scavenger receptor class B type I (SR-BI) inhibitor. HDL376 directly inhibits SR-BI-mediated lipid transport in cells and in liposomes reconstituted with purified SR-BI (IC50 = 0.22 μM). HDL376 can be used for the research of atherosclerotic coronary artery disease.
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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine
0 ImagesCat. No.: HY-154857CAS No.: 89947-80-81-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures.
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1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
0 ImagesCat. No.: HY-168371CAS No.: 161923-56-41-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) is an oxidized phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HODE (HY-113884B) at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC has the ability to compete for the binding of 125I-NO2-LDL (5 g/mL) to CD36-transfected 293 cells, with the IC50 of ＞ 200 μM.
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ML279
0 ImagesCat. No.: HY-124666CAS No.: 1604821-55-7ML279 is a potent scavenger receptor, class B, type I (SR-BI) inhibitor. ML279 can inhibit SR-BI-mediated lipid uptake by stabilizing the binding of HDL to SR-BI (EC50 = 0.27 μM). ML279 can be used for the researches of infection and cardiovascular disease, such as atherosclerosis and HCV infection.
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