Scavenger Receptor Class B type I (SR-BI）

Scavenger receptor class B member 1; SRB1; CD36 and LIMPII analogous 1 (CLA-1); CD36 antigen-like 1

Scavenger receptor class B type I (SR-BI) is a physiologically relevant HDL receptor that mediates the selective uptake of HDL-derived cholesteryl esters (CEs) in vitro and in vivo. SR-BI is a member of the class B scavenger receptor family, which in mammals includes the cluster determinant 36 (CD36) family, lysosomal integral membrane protein II (LIMPII, a lysosomal protein), and SR-BII, an SR-BI isoform with an alternative C-terminal cytoplasmic tail. SR-BI is primarily located on the cell surface, where its expression is regulated by trophic hormones (adrenocorticotropic hormone [ACTH] or the gonadotropins luteinizing hormone [LH] or follicle-stimulating hormone [FSH]), as well as regulating steroid hormone production. SR-BI affects the function of multiple vascular cells associated with atherosclerosis. SR-BI is also involved in regulating platelet function and mediating platelet-HDL interactions^[1].

References:

[1]. Wen-Jun Shen, et al. Scavenger Receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions. Metabolism. 2014 Mar 21;63(7):875–886.

Scavenger Receptor Class B type I (SR-BI） Related Products (11):

By Effects:	Inhibitors (9) Ligand (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-163541

SMS121	Inhibitor	99.06%
SMS121 is a CD36 inhibitor with a K_D values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity.

HY-19900

ITX5061	Inhibitor	99.69%
ITX5061 is an orally active type II non-competitive p38 MAPK inhibitor. ITX5061 increases HDL-C levels by inhibiting SR-BI activity. ITX5061 also moderately elevates ApoA-I levels. ITX5061 reduces early atherosclerotic lesions in the aortic arch of mice fed an atherogenic diet. ITX5061 can be used in the research of atherosclerosis.

HY-P990352

Anti-CD36 Antibody	Inhibitor	99.43%
Anti-CD36 Antibody is a humanized antibody expressed in CHO that targets CD36. The Anti-CD36 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-CD36 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991911

PLT012	Inhibitor
PLT012 is a humanized IgG4 antibody targeting CD36. PLT012 inhibits the lipid-binding domain of CD36. PLT012 blocks CD36-mediated metabolic adaptation in regulatory T cells (Tregs) and CD8⁺ tumor-infiltrating lymphocytes (TILs), thereby inhibiting tumor growth and shifting the tumor microenvironment from immunosuppressive to immunosupportive. PLT012 reduces intratumoral Tregs, enhances CD8⁺ T cell infiltration and cytotoxic function, and increases the abundance of progenitor-exhausted T cells. PLT012 exerts robust antitumor activity and synergizes with anti-PD-L1 or standard-of-care regimens (anti-VEGF + anti-PD-L1). PLT012 can be used for hepatocellular carcinoma, colorectal cancer and solid tumor research.

HY-119770

HDL376	Inhibitor	98.62%
HDL376 is a scavenger receptor class B type I (SR-BI) inhibitor. HDL376 directly inhibits SR-BI-mediated lipid transport in cells and in liposomes reconstituted with purified SR-BI (IC₅₀ = 0.22 μM). HDL376 can be used for the research of atherosclerotic coronary artery disease.

HY-122068

ITX5061 free base	Inhibitor
ITX5061 free base is an orally active type II non-competitive p38 MAPK inhibitor. ITX5061 free base increases HDL-C levels by inhibiting SR-BI activity. ITX5061 free base also moderately elevates ApoA-I levels. ITX5061 free base reduces early atherosclerotic lesions in the aortic arch of mice fed an atherogenic diet. ITX5061 free base can be used in the research of atherosclerosis.

HY-120433

BLT-3	Inhibitor
BLT-3 is an inhibitor of scavenger receptor class B type I (SR-BI) that exerts reversible, non-cell-type-specific inhibitory effects on SR-BI-mediated lipid transport. BLT-3 inhibits SR-BI-mediated selective lipid uptake from HDL as well as cholesterol efflux from cells to HDL. BLT-3 enhances the binding of HDL to SR-BI. BLT-3 is applicable to research related to atherosclerosis and coronary heart disease.

HY-19616

ML278	Inhibitor
ML278 is an efficient, low toxicity, and plasma stable SR-BI (IC₅₀ = 6 nM) lipid uptake inhibitor. ML278 enhances HDL binding while inhibiting SR-BI mediated lipid uptake. ML278 can be used for research on metabolic conditions.

HY-154857

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine	Ligand
1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures.

HY-168371

1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC
1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) is an oxidized phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HODE (HY-113884B) at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC has the ability to compete for the binding of 125I-NO2-LDL (5 g/mL) to CD36-transfected 293 cells, with the IC₅₀ of ＞ 200 μM.

HY-124666

ML279	Inhibitor
ML279 is a potent scavenger receptor, class B, type I (SR-BI) inhibitor. ML279 can inhibit SR-BI-mediated lipid uptake by stabilizing the binding of HDL to SR-BI (EC₅₀ = 0.27 μM). ML279 can be used for the researches of infection and cardiovascular disease, such as atherosclerosis and HCV infection.

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